Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice
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چکیده
منابع مشابه
Tamoxifen prevents bone loss in castrated male mice.
The selective estrogen receptor modulator tamoxifen was administered to intact and castrated male mice, and its effects on tibial bones and circulatory calcium, phosphate and testosterone were compared with controls and castrated animals. Tamoxifen in a dose used in humans for treatment of breast cancer decreased the weight of seminal vesicles, an organ which is highly sensitive to the androgen...
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Activation of G protein-coupled receptors by agonists leads to receptor phosphorylation, internalization of ligand receptor complexes, and desensitization of hormonal response. The role of parathyroid hormone (PTH) receptor 1, PTHR1, is well characterized and known to regulate cellular responsiveness in vitro. However, the role of PTHR1 phosphorylation in bone formation is yet to be investigate...
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ژورنال
عنوان ژورنال: JBMR Plus
سال: 2021
ISSN: 2473-4039,2473-4039
DOI: 10.1002/jbm4.10450